TWO UNUSUAL PRESENTATIONS OF CHILDHOOD BRUCELLA CASES

Two Unusual Presentations of Childhood Brucella Cases

Introduction: Brucellozis is still a common infectious disease in our country and sometimes it may be presented with uncommon clinical manifestations.Case 1: A ten years old male was presented to our clinic with complaints of malaise, weight loss, petechia, and bleeding of gums.On physical examination cervical lymphadenopathy and hepatosplenomegaly

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Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays

Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition.This is because PTR1 can reduce pterins and folates.Trypanosomes require folates and pterins for survival and are unable to synthesize them de novo.Currently there are no Accessories anti-folate b

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Myoblast-derived exosomal Prrx2 attenuates osteoporosis via transcriptional regulation of lncRNA-MIR22HG to activate Hippo pathway

Abstract Background Sarcopenia and osteoporosis are common diseases that predominantly affect older individuals.The interaction between muscle and skeleton exerts pivotal roles in bone remodeling.This study aimed to explore the function of myoblast-derived exosomal Prrx2 in osteogenic differentiation and its potential mechanisms.Methods Exosomes we

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